医学2
各类脂蛋白的临床意义:一、CM正常人空腹12小时后,血浆中CM已完全被清,但I型和V
型高脂蛋白血症病人,空腹血浆中出现高浓度CM。由于CM颗粒大,
不能进入动脉壁内,一般不致动脉粥样硬化,但易诱发胰腺炎。
近年来的研究表明,餐后高脂血症主要是CM浓度升高亦是冠心病的危险因素。
CM的代谢残骸即CM残粒可被巨噬细胞表面受体所识别而摄取,因而可能与动脉粥样硬化有关。
二、VLDL与动脉硬化的关系一直没有定论。以往认为正常的
VLDL不具致动脉粥样硬化的作用,因为它们携带相对少量的胆固醇
另外VLDL颗粒相对大,不易透过动脉内膜。日前多数学者认为,
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